We address several recent claims that the cuprate pseudogap is associated with electronic inversion symmetry breaking. We have implemented a new algorithm for improved
spatial resolution scanning tunneling microscopy, which allows us to image a subtle ~5 picometer inversion-symmetry-breaking structural distortion in
Bi2Sr2Can-1CunO2n+4+x. Although this structural distortion can impact electronic measurements, we show from its
insensitivity to temperature, magnetic field and doping, that it cannot be the long-sought pseudogap state.
Nature Materials 11, 585-589 (2012)